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Dynamic Light Scattering Instrument:
Litesizer DLS

  • +6
  • 360°
Model:
  • Particle size measurements from the nanometer to the micrometer range
  • DLS back scatter detection ensures broad concentration range
  • Automatic measurement modes
  • Continuous transmittance measurement

The Litesizer DLS series characterizes nanoparticles and microparticles at the touch of a button. With these dynamic light scattering instruments, you can determine particles in dispersion and peptides or macromolecules in solution over a broad concentration range, which reduces your sample preparation time.

Key features

Benefit from the perfect angle choice – whatever your sample

Benefit from the perfect angle choice – whatever your sample

  • Ensure high resolution of different size populations via multi-angle particle sizing (MAPS)
  • Choose from three detection angles (side, back, or forward scattering) for optimal parameter settings
  • Manually select the most appropriate angle for your dynamic light scattering instrument or use automatic angle selection 
  • Benefit from the versatile back scattering angle, which is ideal for turbid samples as it reduces multiple scattering events and ensures optimal data quality
Rely on our cmPALS technique for zeta potential measurements

Rely on our cmPALS technique for zeta potential measurements

  • Perform zeta potential measurements via electrophoretic light scattering with Litesizer DLS 700 and Litesizer DLS 500
  • Conduct highly sensitive measurements at low sample concentrations (down to 0.1 mg/mL) with our patented cmPALS technique (European Patent 2 735 870) 
  • Enjoy shorter measuring times and minimal sample degradation with cmPALS
  • Get highly reproducible zeta potential measurements with our unique Ω-shaped capillary of the zeta potential cuvettes
Stay flexible with the particle concentration measurement mode

Stay flexible with the particle concentration measurement mode

  • Perform calibration-free particle concentration measurements of up to three different size populations present within one sample with Litesizer DLS 700
  • Use this mode based on single angle DLS or multi-angle particle sizing (MAPS) to ensure the applicability to monodisperse and polydisperse samples over a wide concentration range
Get continuous transmittance measurements for sample monitoring

Get continuous transmittance measurements for sample monitoring

  • Enjoy instant feedback on your sample – the dynamic light scattering instruments continuously measure transmittance
  • Take advantage of automatic optimization of measurement parameters (e.g., measurement angle, focus position, duration) 
  • Access information about the onset of sedimentation or aggregation within a series measurement
Determine refractive index with the same instrument

Determine refractive index with the same instrument

  • Measure refractive index of the solvent at the exact wavelength and temperature of DLS or ELS measurements (European Patent 3 023 770) with Litesizer DLS 700 and Litesizer DLS 500 
  • Ensure maximum accuracy of particle size and zeta potential results under all experimental conditions
  • Determine the refractive index within ±0.5 % with Litesizer DLS 700 and Litesizer DLS 500

 

Control your measurements with just a few clicks

Control your measurements with just a few clicks

  • Manage data with Kalliope, our user-friendly, particle sizing software
  • Know your input parameters, measurement signals, and results at a glance with our unique one-page workflow 
  • Quickly see your measurement results thanks to predefined standard reports and structured result overviews 
  • Take a deep dive into your data with an analysis function, Excel export, and customizable report templates
  • Comply with 21 CFR Part 11

Technical specifications

  Litesizer DLS 700 Litesizer DLS 500 Litesizer DLS 100
Particle size specifications
Measurement principle Dynamic Light Scattering (DLS)
Measuring range 0.3 nm to 10 μm (particle diameter)
Measurement angles 15°, 90°, 175°, Multi-angle particle sizing (MAPS) 15°, 90°, 175° 175°
Min. concentration 0.1 mg/mL (lysozyme)
lower than 0.00001 % (0.1 ppm, Latex 100 nm)    
0.1 mg/mL (lysozyme)
Max. concentration 50 % w/v (sample-dependent)
Min. sample volume 12 µL
Accuracy Better than +/-2 % on NIST traceable standards
Repeatability Better than +/-2 % on NIST traceable standards
Particle Concentration Specifications
Analysis model Mie Theory - -
Measuring range 108 - 1013 particles/mL (sample dependent) - -
Size limit 1 µm - -
Measurement angles 15°, 90°, 175°, Multi-angle particle sizing (MAPS) - -
Min. sample volume 12 µL - -
Accuracy +/- 10 % (sample dependent) - -
Repeatability +/- 5 % (sample dependent) - -
Zeta potential specifications
Measuring principle Electrophoretic Light Scattering (ELS) / cmPALS -
Measuring range >= +/-1000 mV -
Mobility range 10 -11 m²/V.s to 2 x 10 -7 m²/V.s -
Size range 3.8 nm to 100 µm (diameter) -
Min. sample concentration 0.1 mg/mL (lysozyme) -
Max. sample concentration 70 %w/v (sample-dependent) -
Max. sample conductivity 200 mS/cm -
Min. sample volume 50 µL (sample-viscosity-dependent) -
Accuracy Better than +/-10 % -
Repeatability +/-3 % -
Molecular mass specifications
Measuring principle Static Light Scattering (SLS) -
Measuring range (mass) 300 Da to 20 MDa -
Measuring range (particle size) Up to 40 nm (diameter) -
Measurement angle 90° -
Min. sample concentration 0.1 mg/mL (lysozyme) -
Accuracy +/-10 % -
Repeatability +/-5 % -
Transmittance specifications
Measuring range 0 % to 100 %
Min. sample volume 15 µL
Accuracy Better than +/-1 %
Refractive index specifications
Measuring range 1.28 to 1.50 -
Min. sample volume 1 mL -
Accuracy +/-0.5 % -
General specifications
Light source Semiconductor laser diode / 40 mW, 658 nm
Laser warm-up time 6 min
Temperature control range 0 °C to 90 °C
Ambient operating temperature 10 °C to 35 °C
Humidity Up to 80 % non-condensing
Dimensions (W, D, H) 460 mm, 485 mm, 135 mm
Weight Approx. 18 kg (40 lb) Approx. 16.3 kg (36 lb)

Standards

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ASTM

D4001 500, 700
E2490 100, 500, 700
E2865 500, 700
E3247 100, 500, 700

ISO

13099-2 500, 700
22412 100, 500, 700

US Pharmacopoeia (USP)

430 - Particle Size Analysis by Dynamic Light Scattering 100, 500, 700
432 - Determination of Zeta Potential by Electrophoretic Light Scattering 500, 700
729 - Globule Size Distribution in Lipid Injectable Emusions 100, 500, 700
1153 - Drug Products Containing Nanomaterials 500, 700
1154 - Liposome Drug Products 500, 700
1430 - Analytical Methodologies Based on Scattering Phenomena - General 100, 500, 700

Anton Paar Certified Service

The Anton Paar quality in service and support:
  • More than 350 manufacturer-certified technical experts worldwide
  • Qualified support in your local language
  • Protection for your investment throughout its lifecycle
  • 3-year warranty
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Not all items are purchasable online in specific countries.

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O-RING FOR MEASUREMENT FRAME LIQUID FLOW DISPERSION UNIT

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 253103
Product details
O-ring 75 X 2.5 FKM for measuring cell glass frame in Liquid Flow measurement cell

SYRINGES 2 ml LUER (100 pcs.)

Compatible with:
Litesizer DLS 100 | 500
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Delivery time: %1$s – %2$s working days %1$s – %2$s weeks %1$s – %2$s months
Part number: 6771

SAMPLE AND CLEANING KIT

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 264542

SYRINGES 5 ml LUER (100 pcs.)

Compatible with:
Litesizer DLS 100 | 500
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Part number: 6772

LOW-VOL. DISPOSABLE CUVETTE SET (Uvette)

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 175573
Product details
80 disposable low volume cuvettes (Eppendorf Uvette) incl. Litesizer lifter path length: 10 x 2 mm

HOSE 2x4 SILICONE

Compatible with:
Litesizer DLS 100 | 500
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Part number: 51273

OMEGA CUVETTE FOR ZETA & SIZE (10 pcs.)

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 225288

O-RING 25x2 EPDM 70

Compatible with:
Litesizer DLS 100 | 500
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Part number: 74012

BUFFER SOLUTION PH4.01 HAMILTON

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 12554

VIAL 45 mL GLASS (100 Pcs.)

Compatible with:
Litesizer DLS 100 | 500
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Part number: 161744

BUFFER SOLUTION PH7.00 HAMILTON

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 12556

QUARTZ CUVETTE 12.5 x 12.5 x 45 mm

Compatible with:
Litesizer DLS 100 | 500
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Part number: 163390

PH STORAGE SOLUTION 500ML HAMILTON

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 12632

DISPOSABLE CUVETTE PS 10 x 10 x 45 mm 1 pack with 100 pcs

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 164435

DISPOSABLE CUVETTE LIDS 1 PACK OF 100 PIECES

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 243334

BUFFER SOLUTION PH10.01 HAMILTON

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 46271

SYRINGE FILTER ANOTOP TYPE 25

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 163388

GLASS CUVETTE 12.5 x 12.5 x 45 mm

Compatible with:
Litesizer DLS 100 | 500
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Part number: 177389

SYRINGE FILTER ANOTOP TYPE 10

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 163385

LOW VOLUME CUVETTE QUARTZ 45 µl 12.5 x 12.5 x 45 mm

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 163391

ZETA POTENTIAL CONTROL

Compatible with:
Litesizer DLS 500
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Part number: 227385
Product details
Pack of 6 syringes (3 ml each)

100 nm NIST TRACEABLE SIZE STANDARD

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 165155

HOSE 1x2 SILICONE

Compatible with:
Litesizer DLS 500
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Part number: 67679

220 nm NIST TRACEABLE STANDARD 0.002 %

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 182213

Dosing System

Compatible with:
Litesizer DLS 500
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Product details
  • Accessory for Litesizer 500
  • Automatically modifies the pH or adds solvents – saving time, and eliminating human error
  • Use pH ramp templates in the software to set up your experiments
  • Self-cleaning, no risk of sample carryover

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USB CABLE

Compatible with:
Litesizer DLS 100 | 500 | 700
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Part number: 94228

Software for particle analysis:
Kalliope 

Compatible with:
Litesizer DLS 100 | 500 | 700
Online price only | excl.incl. 0VAT
Delivery time: %1$s – %2$s working days %1$s – %2$s weeks %1$s – %2$s months
Product details
  • Particle analysis software for Anton Paar particle analyzers
  • Start your particle measurements in just three clicks
  • One-page workflow user interface
  • Live monitoring of measurement results
  • Analysis, reporting, and exporting

More info